Molecular-level characterization of elastin-like constructs and human aortic elastin

Elastin Based Constructs

Molecular biology and pathology of human elastin.

22. M., Ninomiya, Y. & Olsen, H. K. (198%) J. Hiol. Chem. 263.2324-2329 Yada, T., Suzuki. S., Kobayashi, K., Kobayashi, M., Hoshino, T., Horie. K. & Kimata, K. (1000) J. Hiol. Chem. 265,6092-6990 Gordon. M. K., Gerecke, L). R. & Olsen, H. K. (1 987) I’roc. Natl. Acad. Sci. LISA. 84. 6040-6044 Llublet, H. & van der Rest, M. (1987) J. Hiol. Chem. 262. 1772417727 Dublet, H., Oh, S., Sugrue, S. I)....

Supravalvular aortic stenosis: elastin arteriopathy.

Supravalvular aortic stenosis is a systemic elastin (ELN) arteriopathy that disproportionately affects the supravalvular aorta. ELN arteriopathy may be present in a nonsyndromic condition or in syndromic conditions such as Williams-Beuren syndrome. The anatomic findings include congenital narrowing of the lumen of the aorta and other arteries, such as branches of pulmonary or coronary arteries....

Molecular-level insights into aging processes of skin elastin.

Skin aging is characterized by different features including wrinkling, atrophy of the dermis and loss of elasticity associated with damage to the extracellular matrix protein elastin. The aim of this study was to investigate the aging process of skin elastin at the molecular level by evaluating the influence of intrinsic (chronological aging) and extrinsic factors (sun exposure) on the morpholo...

Interaction of low density lipoproteins with human aortic elastin.

Interaction between lipoproteins and elastin in the arterial wall may play an important role in atherosclerotic lipid deposition, but binding affinities and other characteristics of the interaction have not been determined previously. Elastin was isolated by hot alkali treatment of human aortic tissue. At 4 degrees C, radioiodinated human low density lipoprotein (LDL) bound to more than one cla...